ESTELLE S. HARRIS, M.D.

LAB WEBSITE

B.A. 1984, Claremont Men's College
M.D. 1988, University of Colorado School of Medicine

RESEARCH:

Our laboratory is interested in monocytes and T lymphocytes and their roles in pulmonary inflammatory diseases including pneumonia, acute lung injury/ARDS, interstitial pneumonitis and transplant rejection.. The current projects that are ongoing in the laboratory include the following: 1) We are exploring the hypothesis that adhesion-mediated signaling of peripheral T lymphocytes via different adhesion receptors (i.e. the integrins 1 and 2 vs. the intracellular adhesion molecule-3 (ICAM-3) results in unique patterns of gene expression; and 2) We are exploring different monocyte subsets present in critically ill patients at risk for acute lung injury (sepsis and trauma) in attempt to understand why some patients recover without lung involvement and others proceed on to ALI/ARDS. We testing the hypothesis that a unique phenotype of "more mature" macrophage/like monocytes are more prevelent in patients that develop ALI/ARDS.

SELECT PUBLICATIONS:

Romzek NC, Harris ES, Dell CL, Skronek J, Hasse E, Reynolds PJ, Hunt SW, Shimizu Y. Use of 1 integrin-deficient human T cell to identify 1 integrin cytoplasmic domain sequences critical for integrin function. Molecular Biology of the Cell 9:2715-2727, 1998.

Harris ES, Shigeoka AO, Li W, Adams RH, Prescott SM, McIntyre TM, Zimmerman GA, Lorant DE. A novel syndrome of variant leukocyte adhesion deficiency involving defects in signaling of 1 and 2 integrins. Blood 97(3):767-776, 2001.

Harris ES, Prescott SM, McIntyre TM, Zimmerman, GA. Minireview: The leukocyte integrins. The Journal of Biological Chemistry 275:23409-23412, 2000.

Bunting M and Harris ES (co-1st authors), McIntyre TM, Prescott, SM and Zimmerman GA. Luekocyte adhesion deficiency syndromes: adhesion and tethering defects involving 2 integrins and selectin ligands. Current Opinion in Hematology, 9:30-35, 2002.