ERIC HANSON, Ph.D.

B.S.
M.S.
PhD. Oregon State University
Postdoctoral fellow at the University of Utah

RESEARCH:

Our interests are centered on how cells sense changes in oxygen concentration and how hypoxia (decreased oxygen) affects cellular function. More specifically we are focused on the mechanisms by which hypoxia regulates protein stability. We are using the RNA binding protein iron regulatory protein 2 (IRP2) as a model to investigate the impact of oxygen on protein stability. Furthermore, since IRP2 is a ubiquitous protein important in the control of cellular iron homeostasis, understanding the nature of its hypoxic regulation will provide insights on the relationship between oxygen and iron homeostasis.

SELECT PUBLICATIONS:

Regulation of iron regulatory protein 1 during hypoxia and hypoxia/reoxygenation. Hanson ES, Leibold EA.J Biol Chem (1998) 273:7588-93.

Hypoxia post-translationally activates iron-regulatory protein 2.Hanson ES, Foot LM, Leibold EA. J Biol Chem (1999) 274:5047-52.

Regulation of the iron regulatory proteins by reactive nitrogen and oxygen species. Hanson ES, Leibold EA. Gene Expr (1999) 7(4-6):367-76.